Troels Holger VaabenScientist · DTU BRIGHT

Scientific work

Publications.

Microbial therapeutics, host responses, and the biology between them.

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2026

  1. Frontiers in Immunology 17, 1925200

    Saccharomyces boulardii reduces food intake and attenuates weight gain in diet-induced obese mice: links to gut microbial, metabolic, and immune remodeling

    KA Hedin, TH Vaaben, DO Lützhøft, BAH Jensen, MOA Sommer

    doi: 10.3389/fimmu.2026.1925200

  2. Gut Microbes 18 (1), 2690687

    Multi-omics analysis of Saccharomyces boulardii supplementation reveals coordinated microbiome, metabolic, and immune signaling changes accompanying tumor suppression

    TH Vaaben, DO Lützhøft, KA Hedin, L Ahonen, R Vazquez-Uribe, MOA Sommer

    doi: 10.1080/19490976.2026.2690687

  3. iScience 29 (5), 115706

    Genomic and phenotypic comparisons reveal lineage-specific traits of the probiotic Saccharomyces boulardii

    HE Duffey, KA Hedin, HP Gelli, TH Vaaben, MOA Sommer

    doi: 10.1016/j.isci.2026.115706

2025

  1. Nature Communications 16 (1), 663

    Metagenome-guided culturomics for the targeted enrichment of gut microbes

    J Armetta, SS Li, TH Vaaben, R Vazquez-Uribe, MOA Sommer

    doi: 10.1038/s41467-024-55668-y

  2. EMBO Reports 26 (7), 1688–1708

    Modulating tumor immunity using advanced microbiome therapeutics producing an indole metabolite

    TH Vaaben, DO Lützhøft, A Koulouktsis, IM Dawoodi, C Stavnsbjerg, L Kvich, I Gögenur, R Vazquez-Uribe, MOA Sommer

    doi: 10.1038/s44319-025-00386-9

  3. Journal of Agricultural and Food Chemistry 73 (24), 15199–15214

    Advanced Microbiome Therapeutics Accelerate MASLD Recovery by Restoring Intestinal Microbiota Equilibrium and the Gut-Liver Axis in a Mouse Model

    J Lok, C Chen, V Iannone, AF Babu, EKK Lo, R Vazquez-Uribe, TH Vaaben, M Kettunen, O Savolainen, U Schwab, MOA Sommer, K Hanhineva, M Kolehmainen, H El-Nezami, C Gómez-Gallego

    doi: 10.1021/acs.jafc.5c01674

2024

  1. The ISME Journal 18 (1), wrae212

    Saccharomyces boulardii enhances anti-inflammatory effectors and AhR activation via metabolic interactions in probiotic communities

    KA Hedin, MH Mirhakkak, TH Vaaben, C Sands, M Pedersen, A Baker, R Vazquez-Uribe, S Schäuble, G Panagiotou, A Wellejus, MOA Sommer

    doi: 10.1093/ismejo/wrae212

2023

  1. Scientific Reports 13 (1), 12506

    Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy

    S Tumas, TS Meldgaard, TH Vaaben, S Suarez Hernandez, AT Rasmussen, R Vazquez-Uribe, SR Hadrup, MOA Sommer

    doi: 10.1038/s41598-023-39365-2

  2. Molecular Metabolism 78, 101823

    Changes in liver metabolic pathways demonstrate efficacy of the combined dietary and microbial therapeutic intervention in MASLD mouse model

    V Iannone, AF Babu, J Lok, C Gómez-Gallego, G D'Auria, R Vazquez-Uribe, TH Vaaben, M Bongers, S Mikkonen, M Vaittinen, I Tikkanen, M Kettunen, A Klåvus, R Sehgal, D Kaminska, J Pihlajamaki, K Hanhineva, H El-Nezami, MOA Sommer, M Kolehmainen

    doi: 10.1016/j.molmet.2023.101823

2022

  1. ACS Synthetic Biology 11 (12), 4184-4192

    Characterization of eight bacterial biosensors for microbial diagnostic and therapeutic applications

    TH Vaaben, R Vazquez-Uribe, MOA Sommer

    doi: 10.1021/acssynbio.2c00491